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Chipping away at diagnostics for neurodegenerative diseases
1Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 65 Landsdowne Street, Suite 307A, Cambridge, MA 02139, USA. cscherzer@rics.bwh.harvard.edu
Genome-wide expression technologies are crucial for discovering novel biomarkers in neurodegenerative diseases. Advances in these methods promise more reliable neurogenomic biomarkers for diagnostics and therapeutics.
Area of Science:
- Neuroscience
- Genomics
- Biomarker Discovery
Background:
- Neurodegenerative diseases require disease-modifying therapeutics.
- Genome-wide expression technologies offer comprehensive molecular biomarker searches.
- The human transcriptome complexity is expanding.
Purpose of the Study:
- To highlight the role of genome-wide expression technologies in neurodegenerative disease research.
- To discuss the maturation and reliability of these technologies for clinical applications.
- To explore the potential of neurogenomic biomarkers for future diagnostics.
Main Methods:
- Utilizing evolving genome-wide expression technologies.
- Leveraging advances in pre-analytical and analytical methods.
- Analyzing transcriptome data for biomarker identification.
Main Results:
- Discovery of osteopontin in multiple sclerosis.
- Identification of SORL1/LR11 in Alzheimer's disease.
- Indication of potential for neurogenomic biomarker identification.
Conclusions:
- Genome-wide expression technologies are vital for biomarker discovery in neurodegenerative diseases.
- Improved methods enhance search efficiency and reproducibility.
- These advancements may yield future neurologic diagnostic candidates.
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