Related Experiment Video

Updated: Jun 24, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Homocysteine and lipoprotein (a) correlation in ischemic stroke patients

Rajinder K Dhamija1, P Gaba, S Arora

  • 1Department of Medicine, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India. dhamijark@hotmail.com

Journal of the Neurological Sciences
|March 17, 2009
PubMed

Insights

Elevated homocysteine and Lipoprotein (a) levels are independently linked to ischemic stroke. These factors show a strong positive correlation, suggesting they may interact to increase stroke risk.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Neurology

Background:

  • Homocysteine and Lipoprotein (a) are known coronary heart disease risk factors.
  • Their specific role in ischemic stroke pathogenesis remains unclear.
  • This study investigates their association with ischemic stroke.

Purpose of the Study:

  • To evaluate plasma homocysteine and serum Lipoprotein (a) levels in ischemic stroke patients.
  • To determine the relationship between these biomarkers and ischemic stroke.
  • To assess potential independent associations and correlations.

Main Methods:

  • Study included consecutive acute ischemic stroke patients and matched healthy controls.
  • Plasma homocysteine measured by ELISA.
  • Serum Lipoprotein (a) quantified using immunoturbidimetric assay.

Main Results:

  • Ischemic stroke patients exhibited significantly higher homocysteine (28.40±2.08 µmol/L) and Lipoprotein (a) (57.33±4.40 mg/dL) levels compared to controls (p<0.001).
  • Raised homocysteine (OR=15.7) and Lipoprotein (a) (OR=8.62) were independently associated with stroke.
  • A strong positive correlation (r=0.75, p<0.001) was found between homocysteine and Lipoprotein (a) levels.

Conclusions:

  • Elevated homocysteine and Lipoprotein (a) are independently associated with ischemic stroke.
  • A significant positive correlation exists between these two biomarkers.
  • Elevated homocysteine may influence Lipoprotein (a) toxicity in ischemic stroke.
Abstract

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...