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Homocysteine and lipoprotein (a) correlation in ischemic stroke patients
Rajinder K Dhamija1, P Gaba, S Arora
1Department of Medicine, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India. dhamijark@hotmail.com
Journal of the Neurological Sciences
|March 17, 2009
Summary
Elevated homocysteine and Lipoprotein (a) levels are independently linked to ischemic stroke. These factors show a strong positive correlation, suggesting they may interact to increase stroke risk.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Neurology
Background:
- Homocysteine and Lipoprotein (a) are known coronary heart disease risk factors.
- Their specific role in ischemic stroke pathogenesis remains unclear.
- This study investigates their association with ischemic stroke.
Purpose of the Study:
- To evaluate plasma homocysteine and serum Lipoprotein (a) levels in ischemic stroke patients.
- To determine the relationship between these biomarkers and ischemic stroke.
- To assess potential independent associations and correlations.
Main Methods:
- Study included consecutive acute ischemic stroke patients and matched healthy controls.
- Plasma homocysteine measured by ELISA.
- Serum Lipoprotein (a) quantified using immunoturbidimetric assay.
Main Results:
- Ischemic stroke patients exhibited significantly higher homocysteine (28.40±2.08 µmol/L) and Lipoprotein (a) (57.33±4.40 mg/dL) levels compared to controls (p<0.001).
- Raised homocysteine (OR=15.7) and Lipoprotein (a) (OR=8.62) were independently associated with stroke.
- A strong positive correlation (r=0.75, p<0.001) was found between homocysteine and Lipoprotein (a) levels.
Conclusions:
- Elevated homocysteine and Lipoprotein (a) are independently associated with ischemic stroke.
- A significant positive correlation exists between these two biomarkers.
- Elevated homocysteine may influence Lipoprotein (a) toxicity in ischemic stroke.
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