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Updated: Jun 24, 2026

Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

Published on: March 1, 2016

Engineering thermoresponsive polymeric nanoshells.

Daniel Cohn¹, Hagit Sagiv, Alexandra Benyamin

¹Casali Institute of Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Givat Ram Campus, Jerusalem 91904, Israel. dcohn18@gmail.com

|March 17, 2009

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Researchers developed thermoresponsive nanostructures that change size with temperature. These biodegradable hollow nanoshells and nanotubes show promise for drug delivery and tissue engineering applications.

Area of Science:

Materials Science
Polymer Chemistry
Nanotechnology

Background:

Amphiphilic molecules self-assemble into micelles.
Thermoresponsive polymers exhibit temperature-dependent properties.
Controlled nanoscale structures are crucial for biomedical applications.

Purpose of the Study:

To synthesize and characterize novel hollow nanoscale constructs with significant thermoresponsive behavior.
To investigate the temperature-dependent dimensional changes of these nanostructures.
To explore the potential for biodegradability and tunable transition temperatures.

Main Methods:

Intra-micellar crosslinking of functionalized poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblocks.
Synthesis of spherical nanoshells and rod-like nanotubes.

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Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

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Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

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Published on: March 1, 2016

Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties

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Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

Incorporation of aliphatic oligoesters for biodegradability.

Main Results:

Spherical nanoshells (200 nm at 15°C) reversibly shrink to ~40 nm around 28°C.
Nanotubes were formed from rod-like micelles at higher temperatures.
Transition temperature is tunable (25°C to >37°C) by altering triblock composition.
Biodegradable nanoshells were successfully synthesized.

Conclusions:

A novel family of thermoresponsive, hollow nanoscale constructs was successfully generated.
These nanostructures exhibit significant, reversible size changes within a narrow temperature range.
The tunable transition temperatures and biodegradability offer versatile platforms for biomedical applications, including drug/gene delivery, tissue engineering, and biosensors.