Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Application of Integration: Problem Solving01:30

Application of Integration: Problem Solving

The process of breathing involves the periodic intake and expulsion of air, known as the respiratory cycle, which typically lasts about five seconds. Modeling the volume of air inhaled into the lungs as a function of time provides insight into both the dynamics and efficiency of pulmonary ventilation. This volume is determined by integrating the airflow rate over time, which captures the cumulative effect of air entering the lungs.Sinusoidal Model of AirflowAirflow during respiration is not...
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Mathematical Modeling: Problem Solving01:29

Mathematical Modeling: Problem Solving

Mathematical modeling transforms real-world scenarios into mathematical expressions, allowing for structured problem-solving and analysis. This process involves defining the situation, assigning variables to measurable quantities, selecting an appropriate model, and solving the resulting equation. Such models are invaluable in finance, providing precise methods to evaluate investments, loans, and repayment structures.A widely used example is the calculation of fixed monthly payments on a loan,...
Alterations in Respiration II01:30

Alterations in Respiration II

There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes include...
Neural Control of Respiration01:18

Neural Control of Respiration

The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complex I drives glutamine-dependent TCA cycle to support viability of MYC<sup>high</sup> breast cancer cells.

Cell reports·2026
Same author

Predicting drug combination response surfaces.

npj drug discovery·2026
Same author

Standardized workflow enables reproducibility of drug synergism detection: Results from a multi-center in vitro ring test on complex drug combinations in pancreatic cancer models.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Disrupted fluid homeostasis in patients with post-Covid-19 syndrome - a case series.

Frontiers in endocrinology·2026
Same author

A multi-center study on the consistency of drug sensitivity testing in patients with acute myeloid leukemia.

NPJ precision oncology·2026
Same author

Multimodal immunopharmacologic screens identify drugs rewiring the cancer-immune interface.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 24, 2026

Method to Obtain Pattern of Breathing in Senescent Mice through Unrestrained Barometric Plethysmography
09:13

Method to Obtain Pattern of Breathing in Senescent Mice through Unrestrained Barometric Plethysmography

Published on: April 28, 2020

Understanding sleep-disordered breathing through mathematical modelling.

Tero Aittokallio1, Arho Virkki, Olli Polo

  • 1Biomathematics Research Group, Department of Mathematics, University of Turku, FI-20014 Turku, Finland. tero.aittokallio@utu.fi

Sleep Medicine Reviews
|March 17, 2009
PubMed
Summary
This summary is machine-generated.

Mathematical modeling can reveal underlying causes of sleep-disordered breathing, improving diagnosis and enabling personalized treatments for metabolic and cardiovascular risks.

More Related Videos

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Related Experiment Videos

Last Updated: Jun 24, 2026

Method to Obtain Pattern of Breathing in Senescent Mice through Unrestrained Barometric Plethysmography
09:13

Method to Obtain Pattern of Breathing in Senescent Mice through Unrestrained Barometric Plethysmography

Published on: April 28, 2020

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Area of Science:

  • Respiratory physiology
  • Cardiovascular health
  • Metabolic disorders

Background:

  • Undiagnosed sleep-disordered breathing is prevalent and linked to metabolic and cardiovascular diseases.
  • Current diagnostic methods and treatments for these conditions are often suboptimal.
  • Mechanistic links and treatment responses remain poorly understood.

Purpose of the Study:

  • To review mathematical modeling approaches for sleep-related respiratory dysfunctions.
  • To explore how these models translate experimental data into testable hypotheses.
  • To discuss the clinical implications of model-based investigations.

Main Methods:

  • Review of various mathematical modeling techniques applied to respiratory control during sleep.
  • Analysis of how models integrate experimental measurements to understand disease mechanisms.
  • Discussion of the translation of model-derived insights into clinical research.

Main Results:

  • Mathematical modeling offers mechanistic insights into sleep-disordered breathing.
  • Models can bridge the gap between experimental observations and clinical realities.
  • Model-based approaches facilitate the development of tailored treatment strategies.

Conclusions:

  • Mathematical modeling is crucial for understanding the pathophysiology of sleep-related respiratory disorders.
  • This approach can lead to improved diagnostic markers and personalized therapies.
  • Model-based investigations hold significant potential for advancing clinical research and patient care.