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Updated: Jun 24, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Thinking outside the F-box: novel ligands for novel receptors
David E Somers1, Sumire Fujiwara
1Department of Plant Cellular and Molecular Biology, The Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA. somers.24@osu.edu
Abstract:
The importance of regulated proteolysis in the physiology and development of plants is highlighted by the large number of genes dedicated to proteasome-dependent protein degradation. Within the SCF class of E3 ubiquitin ligases are more than 700 F-box proteins that act as recognition modules to specifically target their dedicated substrates for ubiquitylation. This review focuses on very recent studies indicating that some F-box proteins function as phytohormone or light receptors, which directly perceive signals and facilitate specific target-protein degradation to regulate downstream pathways. If this new connection between ligand-regulated proteolysis and signaling proves to be more extensive, an entirely new way of understanding the control of signal transduction is in the offing.
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