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Is intrinsic asthma a hereditary disease?

F Pirson1, D Charpin, M Sansonetti

  • 1Département des Maladies Respiratoires, Hôpital Sainte-Marguerite, Marseille, France.

Allergy
|July 1, 1991
PubMed
Summary

Asthma has a hereditary basis. This study found that both intrinsic asthma and extrinsic asthma show increased familial occurrence, with higher prevalence in siblings of intrinsic asthmatics compared to non-asthmatics.

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Area of Science:

  • Pulmonology
  • Genetics
  • Epidemiology

Background:

  • Asthma is recognized to have a hereditary component based on family, twin, and inbred population studies.
  • However, limited evidence exists regarding the familial occurrence of intrinsic asthma specifically.

Purpose of the Study:

  • To investigate and compare the prevalence of asthma within families of individuals with intrinsic asthma, extrinsic asthma, and those without asthma.
  • To clarify the familial aggregation patterns of different asthma phenotypes.

Main Methods:

  • A comparative study involving three groups: intrinsic asthmatics (negative skin tests, n=117), extrinsic asthmatics (positive skin tests, n=164), and non-asthmatics (n=224).
  • Siblings of participants completed a standardized asthma history questionnaire.

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  • Statistical analysis was performed to compare asthma prevalence across sibling groups.

    • Main Results:

    • Asthma was significantly more prevalent in siblings of intrinsic asthmatics (8.9%) compared to siblings of non-asthmatics (2.4%) (P < 0.001).
    • The prevalence of asthma in siblings of intrinsic asthmatics and extrinsic asthmatics was comparable.
    • These findings indicate a higher familial occurrence for both intrinsic and extrinsic asthma.

    Conclusions:

    • Both intrinsic and extrinsic asthma demonstrate an increased familial occurrence.
    • The study supports a significant hereditary component for both major asthma phenotypes.