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Updated: Jun 24, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

An infant with diffuse lung masses

Miltiadis Douvoyiannis1, Lana Bordy, Esra Fakioglu

  • 1Department of Pediatrics, Division of Pediatric Infectious Diseases, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA. mdouvoyi@montefiore.org

Clinical Pediatrics
|March 17, 2009
PubMed

Insights

Chronic granulomatous disease (CGD) can manifest as invasive pulmonary aspergillosis in infants. Persistent respiratory symptoms warrant investigation for immune deficiencies, not just contamination.

Area of Science:

  • Pediatric Pulmonology
  • Immunology
  • Infectious Diseases

Background:

  • Chronic granulomatous disease (CGD) is a primary immunodeficiency affecting phagocyte function.
  • Invasive pulmonary aspergillosis (IPA) is a serious fungal infection, particularly in immunocompromised individuals.

Observation:

  • A case report details an infant with persistent respiratory distress initially misdiagnosed.
  • Symptoms were attributed to gastroesophageal regurgitation and asthma.

Findings:

  • The infant was diagnosed with CGD presenting as IPA.
  • Isolation of unusual pathogens from non-sterile sites requires thorough investigation.

Implications:

  • This case highlights the importance of considering rare diagnoses in infants with unexplained symptoms.
  • Early identification of immune deficiencies like CGD is crucial for timely intervention and improved outcomes.

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