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Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension
1Division of Endocrinology and Metabolism, Beijing Tongren Hospital affiliated to Capital Medical University, Beijing, China.
Introduction:
We performed a meta-analysis to assess the association of ACE2 G8790A polymorphism with essential hypertension.
Materials And Methods:
The references were retrieved through MEDLINE, Wanfang and VIP Information.The analyses were performed by the software STATA 9.0.
Results:
No significant publication bias was observed.The combined data showed no association of the frequencies of the A allele with essential hypertension odds ratio (OR)=1.09 95% confidence interval (CI)=0.98-1.20;p=0.11 in female patients. No associations were shown between the frequencies of the A allele with the genetic susceptibility to essential hypertension in male patients (OR=1.11 95% CI=0.95-1.29; p=0.19).
Conclusion:
The meta-analysis suggests that ACE2 G8790A polymorphism may not be a genetic risk factor for essential hypertension in a Chinese Han population.
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