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Updated: Jun 24, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
Published on: February 19, 2019
A novel nitroreductase of Staphylococcus aureus with S-nitrosoglutathione reductase activity
Ana Filipa N Tavares1, Lígia S Nobre, Ana M P Melo
1Instituto de Tecnologia Química e Biológica, UNL, Av. da República (EAN), 2780-157 Oeiras, Portugal.
Abstract:
In this report we show that inactivation of the putative nitroreductase SA0UHSC_00833 (ntrA) increases the sensitivity of Staphylococcus aureus to S-nitrosoglutathione (GSNO) and augments its resistance to nitrofurans. S. aureus NtrA is a bifunctional enzyme that exhibits nitroreductase and GSNO reductase activity. A phylogenetic analysis suggests that NtrA is a member of a novel family of nitroreductases that seems to play a dual role in vivo, promoting nitrofuran activation and protecting the cell against transnitrosylation.
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