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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

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An Improved Method for Rapid Intubation of the Trachea in Mice

An Improved Method for Rapid Intubation of the Trachea in Mice

Published on: February 22, 2016

Newer agents for rapid sequence intubation: etomidate and rocuronium.

Kevin Y Ching¹, Carl R Baum

¹Section of Pediatric Emergency Medicine, Department of Pediatrics, Yale-New Haven Children's Hospital, Yale University School of Medicine, New Haven, CT 06504, USA.

Pediatric Emergency Care

|March 17, 2009

Summary

Etomidate and rocuronium are effective sedating and paralyzing agents for pediatric rapid sequence intubation, offering rapid onset and minimal hemodynamic effects. However, etomidate

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Published on: January 13, 2017

Area of Science:

Pediatric Emergency Medicine
Anesthesiology
Critical Care

Background:

Rapid sequence intubation (RSI) is crucial for emergency airway management in critically ill children and adolescents.
Etomidate and rocuronium are increasingly utilized for sedation and neuromuscular blockade during pediatric RSI.
Both agents offer advantages such as rapid onset and favorable hemodynamic profiles.

Purpose of the Study:

To review the safety and efficacy of etomidate and rocuronium in pediatric RSI.
To highlight the benefits and potential controversies surrounding their use.

Main Methods:

Literature review of existing evidence on etomidate and rocuronium in pediatric RSI.
Analysis of pharmacokinetic and pharmacodynamic properties.
Evaluation of adverse effects and contraindications.

Main Results:

Etomidate and rocuronium provide rapid onset of action and are generally well-tolerated hemodynamically.
Rocuronium offers effective intubating conditions, avoiding succinylcholine-related complications.
Etomidate's adrenal suppression raises concerns, particularly in pediatric septic shock cases.

Conclusions:

Current evidence supports the safety of etomidate and rocuronium for pediatric RSI.
Further prospective studies are warranted to solidify their role and address specific patient populations, like those with septic shock.