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Transgenic lettuce seedlings carrying hepatitis B virus antigen HBsAg
Jackson Marcondes1, Ekkehard Hansen
1Biochemical Laboratory of Plants and Microorganisms, School of Agricultural Sciences and Veterinary, UNESP, Jaboticabal, SP, Brazil. jackson@fcav.unesp.br
Abstract:
The obtainment of transgenic edible plants carrying recombinant antigens is a desired issue in search for economic alternatives viewing vaccine production. Here we report a strategy for genetic transformation of lettuce plants (Lactuca sativa L.) using the surface antigen HBsAg of hepatitis B virus. Transgenic lettuce seedlings were obtained through the application of a regulated balance of plant growth regulators. Genetic transformation process was acquired by cocultivation of cotyledons with Agrobacterium tumefaciens harboring the recombinant plasmid. It is the first description of a lettuce Brazilian variety 'Vitória de Verão' genetically modified.
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