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Related Concept Videos

Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
Colonisation of Pathogens01:25

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Updated: Jun 24, 2026

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
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Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Published on: September 20, 2024

Biofilms: microbes and disease.

Madhu Sharma Aparna1, Sarita Yadav

  • 1Department of Microbiology, Sharma PGIMS, Rohtak, Haryana, India. aparnaparmar2008@rediffmail.com

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
|March 17, 2009
PubMed
Summary

Biofilms are bacterial communities that are resistant to antibiotics, often causing chronic infections, especially with medical devices. This review covers biofilm formation, mechanisms, and challenges in detection and eradication.

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A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
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Last Updated: Jun 24, 2026

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
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Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

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A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biomaterials

Background:

  • Biofilms are microbial communities encased in a self-produced matrix, exhibiting enhanced resistance to antimicrobials.
  • Biofilm formation is linked to the transition from acute to chronic infections.
  • Indwelling medical devices are significant risk factors for biofilm-associated infections.

Purpose of the Study:

  • To review the stages of biofilm development.
  • To discuss pathogenic mechanisms of biofilms.
  • To explore challenges and strategies for antimicrobial treatment, detection, and eradication of biofilms.

Main Methods:

  • Literature review of biofilm formation, pathogenesis, and treatment.
  • Synthesis of current knowledge on antimicrobial resistance in biofilms.
  • Analysis of detection and eradication techniques.

Main Results:

  • Biofilms present unique challenges due to inherent antimicrobial resistance.
  • Current antibiotic therapies show limited effectiveness against established biofilms.
  • Effective eradication requires multifaceted approaches targeting different biofilm stages.

Conclusions:

  • Understanding biofilm dynamics is crucial for combating chronic infections.
  • Novel strategies are needed to overcome antimicrobial resistance in biofilms.
  • Integrated approaches for detection and eradication are essential for clinical success.