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Updated: Jun 24, 2026

Invasion of Human Cells by a Bacterial Pathogen

Invasion of Human Cells by a Bacterial Pathogen

Published on: March 21, 2011

Hospital strain colonization by Staphylococcus epidermidis.

D Blum-Menezes¹, O J Bratfich, M C Padoveze

¹Laboratório de Epidemiologia Molecular, Bactérias e Fungos, Disciplina de Infectologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas

|March 17, 2009

Summary

This summary is machine-generated.

Hospitalization can alter skin microbiota, leading to infections. A patient

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Last Updated: Jun 24, 2026

Invasion of Human Cells by a Bacterial Pathogen

Invasion of Human Cells by a Bacterial Pathogen

Published on: March 21, 2011

Area of Science:

Microbiology
Genomics
Infectious Diseases

Background:

Healthy skin hosts diverse Staphylococcus epidermidis strains with unique genomic DNA.
Hospitalization and invasive procedures can disrupt the skin microbiota.
Staphylococcus epidermidis is a common cause of hospital-acquired infections, particularly catheter-related ones.

Observation:

A patient with chronic pancreatitis experienced prolonged hospitalization and multiple invasive procedures.
The patient's initial diverse skin S. epidermidis strains were replaced by a single hospital-acquired strain.
This hospital strain produced biofilms and led to recurrent catheter-related infections.

Findings:

Genomic analysis using pulsed field gel electrophoresis revealed the replacement of the patient's native S. epidermidis strains with a single, hospital-acquired strain.
The acquired strain was identified as a biofilm-producer, contributing to persistent catheter-related infections.
This highlights the dynamic changes in skin microbiota during prolonged hospitalization.

Implications:

Understanding microbial shifts is crucial for preventing hospital-acquired infections.
Targeting biofilm-producing strains could be a strategy for managing recurrent infections.
This case underscores the importance of monitoring and managing skin colonization in hospitalized patients.