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Published on: July 28, 2010

Substantially reduced expression of PIAS1 is associated with colon cancer development

Domenico Coppola1, Vevek Parikh, David Boulware

  • 1Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA. Domenico.Coppola@moffitt.org

Journal of Cancer Research and Clinical Oncology
|March 17, 2009
PubMed
Abstract

Insights

High expression of PIAS1 and IRF-1 correlates with normal colon cells and adenomas, suggesting PIAS1 can help distinguish adenomas from colon cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, impacting tumor development.
  • PIAS proteins also influence STAT family members independent of IFN-gamma signaling.

Purpose of the Study:

  • To assess Protein Inhibitor of Activated STAT1 (PIAS1) expression in colon cancer.
  • To determine if PIAS1 or IFN-gamma pathway components can stratify colon tumors.

Main Methods:

  • Tissue microarrays of colon cancer were stained for PIAS1, interferon regulatory factor-1 (IRF-1), and STAT1alpha.
  • Expression levels were analyzed to identify correlations with tumor status.

Main Results:

  • PIAS1 staining showed a strong correlation between normal colon cells and adenomas with high PIAS1 expression.
  • High expression of IRF-1 was also observed in normal and adenomatous tissues.

Conclusions:

  • PIAS1 expression levels may serve as a biomarker for differentiating adenomas from colon cancer.
  • These findings suggest potential new strategies for colon cancer diagnosis.

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