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Related Experiment Video

Updated: Jun 24, 2026

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
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Published on: April 2, 2017

Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?

Ozgur Firat1, Ozgur Kirdok, Ozer Makay

  • 1Department of General Surgery, Ege University Hospital, 3rd Floor, Bornova, 35100, Izmir, Turkey. ozgur.firat@ege.edu.tr

Journal of Hepato-Biliary-Pancreatic Surgery
|March 17, 2009
PubMed
Summary

Hyperbaric oxygenation (HBO) may reduce chemotherapy-induced liver injury and enhance liver regeneration after portal vein ligation in rats, offering potential benefits for hepatocellular cancer treatment.

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Published on: August 7, 2020

Area of Science:

  • Hepatocellular carcinoma research
  • Regenerative medicine
  • Hyperbaric medicine

Background:

  • Portal vein embolization (PVE) enhances resectability in hepatocellular cancer treatment.
  • Chemotherapeutics like doxorubicin cause hepatocellular injury, restricting liver regeneration post-PVE.
  • Investigating methods to mitigate chemotherapy-induced liver damage is crucial for improving treatment outcomes.

Purpose of the Study:

  • To evaluate the efficacy of hyperbaric oxygenation (HBO) in alleviating doxorubicin-induced hepatotoxicity.
  • To determine if HBO can improve liver regeneration in an injured liver model.
  • To assess HBO's potential role in enhancing liver recovery following chemotherapy and PVE.

Main Methods:

  • Rats underwent right portal vein ligation (RPVL) with or without doxorubicin administration.
  • One group received postoperative hyperbaric oxygenation (HBO) sessions.
  • Liver injury was assessed via ALT and AST levels; regeneration by mitotic index (MI) and albumin levels.

Main Results:

  • Doxorubicin increased liver enzymes (AST, ALT), but HBO mitigated this effect.
  • HBO did not significantly alter albumin levels compared to controls.
  • HBO significantly increased the mitotic index, indicating enhanced liver regeneration compared to RPVL alone.

Conclusions:

  • Hyperbaric oxygenation (HBO) demonstrates potential in reducing doxorubicin-related liver toxicity.
  • HBO treatment appears to improve liver regeneration following injury.
  • HBO may be a valuable adjunct therapy for patients undergoing chemotherapy and liver-directed treatments.