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Anti-inflammatory properties of cryptolepine.

Olumayokun A Olajide1, Abayomi M Ajayi, Colin W Wright

  • 1Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria. olajide705@btinternet.com

Phytotherapy Research : PTR
|March 17, 2009
PubMed
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Cryptolepine, a plant alkaloid, demonstrates significant anti-inflammatory and analgesic effects in animal models. This compound effectively reduces swelling and pain, validating its therapeutic potential in vivo.

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Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Immunology

Background:

  • Cryptolepine is the primary alkaloid from Cryptolepis sanguinolenta.
  • In vitro studies show cryptolepine inhibits nitric oxide production and Nuclear Factor-kappa B (NF-κB) DNA binding.
  • Validation of in vitro anti-inflammatory findings in vivo is necessary.

Purpose of the Study:

  • To investigate the in vivo anti-inflammatory and analgesic properties of cryptolepine.
  • To evaluate the effects of cryptolepine in established animal models of inflammation and pain.
  • To assess the safety profile of cryptolepine regarding gastric effects.

Main Methods:

  • Animal models used include carrageenan-induced rat paw edema and pleurisy, and lipopolysaccharide (LPS)-induced microvascular permeability in mice.
  • Cryptolepine was administered intraperitoneally (i.p.) at doses of 10-40 mg/kg.
  • Analgesic activity was assessed using the acetic acid-induced writhing test in mice.
  • Gastric lesion formation was evaluated after oral administration for four consecutive days.

Main Results:

  • Cryptolepine exhibited dose-dependent inhibition of carrageenan-induced rat paw edema and pleurisy.
  • The compound significantly reduced LPS-induced microvascular permeability in mice.
  • Cryptolepine demonstrated dose-related inhibition of acetic acid-induced writhing, indicating analgesic effects.
  • No gastric lesions were observed in rats treated orally with cryptolepine up to 40 mg/kg.

Conclusions:

  • Cryptolepine possesses significant in vivo anti-inflammatory activity.
  • The compound also exhibits analgesic properties.
  • Cryptolepine appears to be safe for the gastric mucosa at the tested doses.