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Additional Subnuclear Structures

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals.
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...

Additional Subnuclear Structures

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals.
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...

The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

The Nucleus

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

The Nucleus

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

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Related Experiment Video

Updated: Jun 24, 2026

Nitrogen Cavitation and Differential Centrifugation Allows for Monitoring the Distribution of Peripheral Membrane Proteins in Cultured Cells

Nitrogen Cavitation and Differential Centrifugation Allows for Monitoring the Distribution of Peripheral Membrane Proteins in Cultured Cells

Published on: August 18, 2017

The perinucleolar compartment.

Callie Pollock¹, Sui Huang

¹Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Journal of Cellular Biochemistry

|March 17, 2009

Summary

This summary is machine-generated.

The perinucleolar compartment (PNC), a nuclear body found in cancer cells, shows promise as a pan-cancer marker. Its structure depends on RNA transcription and DNA integrity, with ongoing research clarifying its dynamics and function.

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Area of Science:

Cell Biology
Cancer Research
Molecular Biology

Background:

The perinucleolar compartment (PNC) is a nuclear body located at the nucleolar periphery.
PNC is predominantly observed in cancer cells and may serve as a pan-cancer marker for solid tumors.

Purpose of the Study:

To summarize the current understanding of the dynamics, structure, and function of the perinucleolar compartment (PNC).
To highlight the potential of PNC as a diagnostic marker in cancer.

Main Methods:

Review of recent evidence and characterization studies on the PNC.
Analysis of the molecular composition and dynamics of the PNC, including RNA and protein content.
Investigation of factors influencing PNC structural integrity, such as RNA transcription and DNA structure.

Main Results:

The PNC is a heritable structure containing newly transcribed pol III RNAs and RNA-binding proteins.
PNC integrity is contingent upon continuous pol III RNA transcription and intact DNA.
PNC prevalence is suggested as a pan-cancer marker for solid tissue tumors.

Conclusions:

The perinucleolar compartment (PNC) is a dynamic nuclear structure with a crucial role in cancer cells.
Further research is needed to fully elucidate the complete structure and function of the PNC.
PNC characterization offers insights into nuclear organization and potential cancer diagnostics.