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Related Experiment Videos

Adrenocortical carcinoma.

R A Decker1, M E Kuehner

  • 1Department of Surgery, Marshfield Clinic, Wisconsin 54449.

The American Surgeon
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

Adrenal cortical carcinoma treatment outcomes show that surgical resection of recurrent tumors can prolong survival. The drug o,p'-DDD demonstrated significant tumor regression in some patients, unlike chemotherapy or radiotherapy.

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Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Pathology

Background:

  • Adrenal cortical carcinoma is a rare and aggressive endocrine malignancy.
  • Understanding treatment efficacy for advanced or recurrent disease is crucial.

Purpose of the Study:

  • To review treatment outcomes for adrenal cortical carcinoma.
  • To evaluate the effectiveness of surgical resection, o,p omino-DDD, chemotherapy, and radiotherapy.

Main Methods:

  • Retrospective review of ten patients treated for adrenal cortical carcinoma between 1971 and 1989.
  • Analysis of presenting features, tumor characteristics, treatment interventions, and survival data.

Main Results:

  • Seven of ten patients had functioning tumors, often presenting with hormonal excess or metastases.

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  • Surgical resection of primary and recurrent tumors was performed in all patients.
  • o,p omino-DDD achieved objective responses in 43% of patients with metastatic or recurrent disease, including complete regression in two cases.
  • Cytotoxic chemotherapy and abdominal radiotherapy showed no observable response.

    • Conclusions:

    • Surgical resection of local recurrence may improve survival in adrenal cortical carcinoma.
    • o,p omino-DDD is a potentially effective treatment for inducing significant and lasting tumor regression.
    • Current cytotoxic chemotherapy and radiotherapy regimens demonstrated limited efficacy.