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Updated: Jun 24, 2026

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
Published on: April 3, 2018
Viral manipulation of the host epigenome for oncogenic transformation
Roberto Ferrari1, Arnold J Berk, Siavash K Kurdistani
1Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
Abstract:
The cancerous cellular state is associated with multiple epigenetic alterations, but elucidating the precise order of such alterations during tumorigenic progression and their contributions to the transformed phenotype remains a significant challenge in cancer biology. Here we discuss recent findings on how viral oncoproteins exploit specific epigenetic processes to coerce normal cells to replicate when they should remain quiescent - a hallmark of cancer. These findings may highlight roles of epigenetic processes in normal biology and shed light on epigenetic events occurring along the path of non-viral neoplastic transformation.
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