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Related Experiment Video

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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Published on: March 24, 2015

Human TRIM gene expression in response to interferons.

Laetitia Carthagena1, Anna Bergamaschi, Joseph M Luna

  • 1Département des Maladies Infectieuses, Institut Cochin, Université Paris Descartes, CNRS, UMR 8104, Paris, France.

Plos One
|March 18, 2009
PubMed
Summary
This summary is machine-generated.

This study investigated Tripartite Motif (TRIM) gene expression in human immune cells. Many TRIM genes are responsive to interferons (IFNs), suggesting their broader role in antiviral immunity.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Tripartite motif (TRIM) proteins share a conserved architecture.
  • TRIM5alpha's anti-HIV activity highlights TRIM proteins' potential in innate immunity and antiviral defense.

Purpose of the Study:

  • To systematically analyze TRIM gene expression in human primary immune cells.
  • To identify TRIM genes regulated by interferons (IFNs) and FcgammaR activation.

Main Methods:

  • Analysis of TRIM gene expression in human primary lymphocytes and macrophages.
  • Stimulation with type I and II interferons (IFNs) and FcgammaR-mediated activation.

Main Results:

  • 27 of 72 human TRIM genes were found to be IFN-sensitive.
  • 9 additional TRIM genes were identified as IFN-upregulated, with only 3 previously known for antiviral activity.
  • TRIM9 and TRIM54 were specifically up-regulated in FcgammaR-activated macrophages.

Conclusions:

  • This is the first comprehensive TRIM gene expression analysis in primary human immune cells.
  • Additional TRIM proteins are suggested to play roles in regulating host antiviral activities.