Primary leptomeningeal oligodendrogliomatosis
Marlon S Mathews1, Laura S Paré, Jeffery V Kuo
1Department of Neurological Surgery, State University New York at Buffalo, Buffalo, USA. mmathews@buffns.com
Journal of Neuro-Oncology
|March 18, 2009
Summary
Primary leptomeningeal oligodendrogliomas (PLOs) are rare brain tumors. This case report highlights a fourth instance of PLO, emphasizing its potential to mimic meningitis.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Neuropathology
Background:
- Primary leptomeningeal oligodendrogliomas (PLOs) are rare intracranial tumors originating in the subarachnoid space.
- These tumors lack apparent connection to the brain or spinal cord parenchyma.
Observation:
- A 50-year-old woman presented with severe headaches, hydrocephalus on CT, and diffuse leptomeningeal enhancement on MRI.
- Frameless stereotactic biopsy revealed oligodendroglioma histology with clear cytoplasm and rounded nuclei.
Findings:
- This report details the fourth documented case of PLO with no parenchymal involvement.
- The histological findings confirmed the diagnosis of oligodendroglioma.
Implications:
- Primary leptomeningeal oligodendrogliomas can clinically and radiographically mimic granulomatous meningitis.
- Consider PLO in patients presenting with meningitis-like symptoms but lacking infectious or inflammatory markers.
