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Updated: Jun 24, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Pharmacogenetics of the organic anion transporting polypeptide 1A2
Ryan M Franke1, Lisa A Scherkenbach, Alex Sparreboom
1Department of Pharmaceutical Sciences, St Jude Children's Hospital, 332 North Lauderdale, DTRC, Mail Stop 313, Room I5308, Memphis, TN 38105, USA.
Abstract:
The solute carrier, human organic anion transporting polypeptide 1A2 (OATP1A2, OATP-A, OATP1 and OATP) is highly expressed in the intestine, kidney, cholangiocytes and the blood-brain barrier. This localization suggests that OATP1A2 may be vitally important in the absorption, distribution and excretion of a broad array of clinically important drugs. Several nonsynonymous polymorphisms have been identified in the gene encoding OATP1A2, SLCO1A2 (SLC21A3), with some of these variants demonstrating functional changes in the transport of OATP1A2 substrates.
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