Related Experiment Video
Updated: Jun 24, 2026
08:32
Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Borna disease virus: a unique pathogen and its interaction with intracellular signalling pathways
Oliver Planz1, Stephan Pleschka, Thorsten Wolff
1Friedrich-Loeffler-Institute (FLI), 72076 Tübingen, Germany.
Cellular Microbiology
|March 18, 2009
Summary
Borna disease virus (BDV) causes persistent infections in the central nervous system. This review covers how BDV impacts neuronal plasticity, behavior, and immune responses, offering insights into persistent viral infections.
Area of Science:
- Neurovirology
- Immunology
- Molecular Biology
Background:
- Borna disease virus (BDV) is a neurotropic RNA virus causing persistent infections in the central nervous system (CNS).
- BDV infection can lead to altered neuronal plasticity, behavior changes, or fatal T cell-mediated immunopathology.
- BDV serves as a model pathogen for studying persistent CNS viral infections.
Purpose of the Study:
- To review recent findings on how BDV interacts with intracellular signaling pathways.
- To explore the role of these pathways in viral spread, persistence, and neurotransmitter modulation.
Main Methods:
- This is a review article, synthesizing existing research.
- Analysis of published studies on BDV's molecular mechanisms and host interactions.
Main Results:
- BDV interferes with various intracellular signaling pathways.
- These pathways are implicated in viral replication, establishing and maintaining persistent infection.
- BDV's interference impacts neurotransmitter systems, potentially explaining behavioral changes.
Conclusions:
- BDV utilizes host intracellular signaling pathways for its lifecycle and persistence.
- Understanding these interactions is crucial for developing therapeutic strategies against persistent viral CNS infections.
- Further research into BDV's molecular mechanisms can illuminate broader principles of neurovirology.
Related Concept Videos
02:26NF-κB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
01:24Intracellular Signaling Cascades
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
01:24Intracellular Signaling Cascades
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
01:10Intracellular Movement of Viruses and Bacteria
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a virus that...
01:19Interactions Between Signaling Pathways
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
01:19Inhibitors of Virion Maturation and Assembly
As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...