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Updated: Jun 24, 2026
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Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
Published on: July 17, 2020
SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels
1Department of Microbiology and The Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908-0734, USA. ulorenz@virginia.edu
Immunological Reviews
|March 18, 2009
Summary
Protein tyrosine phosphatases (PTPs) are crucial for T-cell function. This review highlights the roles of cytoplasmic PTPs SHP-1 and SHP-2 in T-cell signaling, development, and differentiation.
Area of Science:
- Immunology
- Cell Biology
- Biochemistry
Background:
- Tyrosine phosphorylation is vital for T-cell functions.
- Protein tyrosine kinases (PTKs) are well-studied in T-cell signaling.
- The role of protein tyrosine phosphatases (PTPs) in T-cell regulation is less understood.
Purpose of the Study:
- To review the functions of cytoplasmic PTPs in T-cells.
- To elucidate the importance of SHP-1 and SHP-2 in T-cell biology.
Main Methods:
- Literature review of studies on PTPs in T-cells.
- Focus on cytoplasmic PTPs: SHP-1 and SHP-2.
- Analysis of their roles in T-cell signaling pathways.
Main Results:
- Both transmembrane and cytoplasmic PTPs regulate T-cell responses.
- SHP-1 and SHP-2 are key cytoplasmic PTPs in T-cells.
- These PTPs influence T-cell signaling, development, differentiation, and function.
Conclusions:
- Cytoplasmic PTPs, particularly SHP-1 and SHP-2, are critical regulators of T-cell activities.
- Further research into PTPs is essential for a comprehensive understanding of T-cell immunology.
- Understanding PTPs can reveal new therapeutic targets for T-cell related diseases.
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