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Updated: Jun 24, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Optimization of emulsions.

M E Carlotti¹, R Carpignano, M R Gasco

¹Dipartimento di Scienza e Tecnologia del Farmaco.

International Journal of Cosmetic Science

|March 18, 2009

Summary

This summary is machine-generated.

Researchers optimized emulsions using experimental design, comparing three surfactants. The study found that the counter-ion significantly impacts emulsion composition and stability, with optimized versions showing high stability after centrifugation.

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Particle Templated Emulsification enables Microfluidic-Free Droplet Assays

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Published on: March 9, 2021

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Last Updated: Jun 24, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Particle Templated Emulsification enables Microfluidic-Free Droplet Assays

Particle Templated Emulsification enables Microfluidic-Free Droplet Assays

Published on: March 9, 2021

Area of Science:

Physical Chemistry
Colloid Science
Materials Science

Background:

Emulsions are crucial in various industries, requiring stable formulations.
Surfactant selection is key to controlling emulsion properties.

Purpose of the Study:

To optimize emulsion composition using experimental design.
To compare the efficacy of three different surfactants in emulsion formation and stability.

Main Methods:

Utilized experimental design for systematic optimization.
Investigated emulsions formulated with hexadecylhydrogenphosphate salts and diethanolamine, lysine, or arginine.
Assessed emulsion stability via centrifugation at 7000 rpm for 30-60 minutes.

Main Results:

Optimized microemulsions exhibited high stability under centrifugation.
The choice of counter-ion (diethanolamine, lysine, arginine) influenced emulsion composition.
Significant differences in stability were observed based on the surfactant used.

Conclusions:

Counter-ions play a critical role in determining emulsion characteristics.
The specific surfactant structure affects both the formulation and the final stability of emulsions.
Experimental design is an effective tool for optimizing complex emulsion systems.