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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: Jun 24, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Bone microdamage: a clinical perspective.

R D Chapurlat1, P D Delmas

  • 1INSERM Research Unit 831, Université de Lyon, Hôpital E Herriot, Hospices Civils de Lyon, 69437 Lyon cedex 03, France. roland.chapurlat@inserm.fr

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|March 18, 2009
PubMed
Summary
This summary is machine-generated.

Fatigue loading can cause bone microdamage, potentially leading to fracture. While bisphosphonates may increase microdamage, their clinical impact in humans remains unclear due to assessment difficulties.

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Area of Science:

  • Bone biomechanics
  • Skeletal tissue engineering
  • Osteoporosis research

Background:

  • Microdamage accumulation from fatigue loading is a precursor to bone fracture.
  • Animal studies suggest bisphosphonates may exacerbate microdamage accumulation.

Purpose of the Study:

  • To review literature on microcrack detection techniques.
  • To examine the relationship between microdamage and bone strength.
  • To investigate the influence of anti-osteoporosis agents on bone microdamage.

Main Methods:

  • Literature review via PubMed search.
  • Analysis of techniques for microcrack detection (microscopy).
  • Evaluation of studies on bisphosphonates and bone microdamage in animal models.

Main Results:

  • Microcrack detection currently uses bulk staining and microscopy.
  • Bisphosphonate administration in dogs showed dose-dependent microdamage, but effects on bone mechanics are conflicting.
  • Human data on bisphosphonates and iliac crest microdamage is limited and inconclusive.

Conclusions:

  • Bone microdamage is crucial for understanding bone quality.
  • Assessing microdamage in humans presents significant technical challenges.
  • The clinical significance of drug-induced microdamage in humans is not yet established.