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Updated: Jun 24, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
Published on: June 3, 2018
[Regenerative therapy in cardiology]
T Chatterjee1, J Ortak, I Akin
1Abteilung für Kardiologie, Universitätsklinikum Rostock (D) und Herzzentrum Hirslanden Zentralschweiz, Klinik St. Anna, Luzern, Germany.
Abstract:
The aim of regenerative medicine is the reconstitution of the physiological structure of critically damaged organs. Bone marrow derived stem cells (BMDCs) show promising therapeutic potential. BMDCs are already used in oncology and are ideally suited for regenerative medicine due to their regenerative potential and safety profile. A variety of cells have been contemplated in cardiology, and there is emerging preclinical and clinical data on the feasibility and safety of different cell lines in the setting of acute myocardial infarction and chronic heart failure. In this review, the various concepts and cells will be discussed in further detail.
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