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Updated: Jun 24, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
[Evaluation of "complex syncope: what are the indications for second-level investigations?]
Andrea Ungar1, Alessandro Morrione, Martina Rafanelli
1Centro per lo Studio della Sincope, Cardiologia e Medicina Geriatrica, Università degli Studi, Azienda Ospedaliero-Universitaria Careggi, Firenze.rdiologia, Azienda USL 11, Empoli (FI) aungar@unifi.it
Abstract:
Syncope is a common symptom accounting for 1.1% of all admissions to the emergency department in Italy. Diagnostic and therapeutic management of patients with syncope may be complex and with a major impact on health expenditure. A standardized approach to syncope may reduce diagnostic tests, hospitalizations and health costs. After the initial "gold standard" evaluation, which includes history, physical examination, orthostatic hypotension test and ECG, several diagnostic pathways can be followed. It has been shown that a correct initial evaluation and a thorough knowledge of syncope can reduce needless testing and increase diagnostic yield, optimizing resource management. In this review we aim to underscore the key points of the management of patients with syncope and the main indications for specific second-level examinations, such as those for neuroautonomic evaluation (tilt table test, carotid sinus massage) and implantable loop recorder. The role of Syncope Units in the management of patients with temporary loss of consciousness is also described.
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