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[Hypoxia inducible factor-1alpha expression trends in hippocampus of rat of different ages]
Hai-Qin Wu1, Hu-Qing Wang, He-Na Guo
1Department of Neurology, Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710004, China.
Objective:
To reveal the expression trends of HIF-1alpha in hippocampus of different age rats, investigate the role of HIF-1alpha in the aging process of nervous system.
Methods:
The cerebral tissues was collectd from rats of different age, including 3, 18, 24, 36 months old. There were 6 rats in each age group. The expressions of nissl body and HIF-1alpha in different part of hippocampus were observed by nissl staining and immunohistochemical technique.
Results:
(1) With the increase of rat age, nerve cells appeared to be bigger and to arrange sparsely, while the nissl body decreased; (2) The positive HIF-1alpha staining cells in CA1, CA3 region of hippocampus increased along with the increase of rat age. The difference between any two age groups showed statistical significance (P < 0.05).
Conclusion:
The function of protein synthesis weakened in nerve cells but the expression of HIF-1alpha increased with the age increasing, which may play an important role in aging of nervous system.
