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Updated: Jun 24, 2026
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
[Effect of weight on bone mineral density in ovariectomic rats]
Lin Qiao1, Liang-Zhi Xu, Ding-Zhuo Yang
1Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To evaluate the effect of weight on bone mineral density in ovariectomic rats.
Methods:
Forty 6-month-old Wistar female rats were randomly divided into the sham surgical group and the ovariectomic group. The weights of the rats and the bone mineral densities and bone mineral contents of the femurs of the rats were measured eight weeks after the operations.
Results:
The body weights of the ovariectomic rats increased significantly. The vaginal cytology of the ovariectomic rats showed no estrous cycle. The areas of the uterus transverse section of the ovariectomic rats deceased significantly. The depth of endometrium and its epithelia, and the area percentage of endometric gland of the ovariectomic rats were smaller than those of the sham surgical controls. There were no statistically differences in the BMD and BMC between the ovariectomic rats and the sham surgical controls. However, the BMC/weight ratio of the ovariectomic rats decreased significantly. The linear stepwise regression analysis indicated a positive correlation between BMC and body weight and a negative correlation between BMC and the weight differences pre- and post operations. The BMC/weight ratio also had a negative correlation with the weight differences.
Conclusion:
The osteoporotic animal model after ovariectomy has been successfully established. The certain increased body weight after ovariectomy may slow the lose of bone mass. But the over increasing in body mass lead to BMC/weight decling, caused by osteoporosis.
