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[Pharmacokinetics of PEG recombinant human interleukin-6 in rats]
Xue-Ling He1, Guang Yang, Hai-Lin Yin
1Laboratory Animal Center, Sichuan University, Chengdu 610041, China.
Objective:
To study the pharmacokinetics and tissue distribution of PEG-rhIL-6 in rats after a single dose administration.
Methods:
Pharmacokinetics and distribution of PEG-rhIL-6 in rats were studied by 125I isotope tracing method. Pharmacokinetic analysis was performed using 3P97 computer software.
Results:
PEG-rhIL-6 declined in one-compartment model with half-lives of 10.44-11.37 h for t1/2 Ka, 19.77-21.53 h for t1/2 Ke and 20.51-21.96 h for T(pcak), respectively. PEG-rhIL-6 was mainly distributed in blood and excreted via urine.
Conclusion:
The half-lives of PEG-rhIL-6 are prolonged after being modified by PEG.
