Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Control of renin secretion.

Y Abe, H Iwao, T Okahara

    Japanese Circulation Journal
    |March 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Renin secretion is influenced by renal blood flow and pressure, with the sympathetic nervous system playing a role in late-stage responses. A beta-adrenergic receptor-adenyl cyclase-cAMP system also modulates renin release.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Simultaneous spawning by female stream goby Rhinogobius sp. and the association with brood cannibalism by nesting males.

    Journal of fish biology·2016
    Same author

    Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity.

    Cancer gene therapy·2007
    Same author

    Dominant-negative c-Jun inhibits rat cardiac hypertrophy induced by angiotensin II and hypertension.

    Gene therapy·2005
    Same author

    Angiotensin converting enzyme inhibitor prevents left ventricular remodelling after myocardial infarction in angiotensin II type 1 receptor knockout mice.

    Heart (British Cardiac Society)·2005
    Same author

    Microbubble destruction with ultrasound augments neovascularisation by bone marrow cell transplantation in rat hind limb ischaemia.

    Heart (British Cardiac Society)·2005
    Same author

    Effects of eplerenone on transcriptional factors and mRNA expression related to cardiac remodelling after myocardial infarction.

    Heart (British Cardiac Society)·2005

    Area of Science:

    • Physiology
    • Renal Physiology
    • Cardiovascular Regulation

    Background:

    • Renin secretion is a critical component of the renin-angiotensin-aldosterone system, regulating blood pressure and fluid balance.
    • The interplay between intrarenal vascular receptors, the sympathetic nervous system, and beta-adrenergic pathways in controlling renin release is complex and not fully elucidated.

    Purpose of the Study:

    • To investigate the relationship between intrarenal vascular receptors, the sympathetic nervous system, and the beta-adrenergic system in regulating renin secretion.
    • To determine the roles of renal arterial pressure, blood flow, and specific signaling pathways in renin release.

    Main Methods:

    • Experiments were conducted on anesthetized dogs.
    • Renal arterial pressure was manipulated, and blood flow and renin secretion rates were measured.

    Related Experiment Videos

  • Pharmacological agents (norepinephrine, phenoxybenzamine, propranolol, cAMP, DbcAMP, CaCl2) were infused intrarenally.
  • Plasma renin activity (PRA) was measured during hemorrhagic hypotension.

    • Main Results:

    • Reduced renal arterial pressure to 75 mmHg increased renin secretion and decreased outer cortex blood flow.
    • Norepinephrine infusion suppressed renin release at reduced pressure.
    • The sympathetic nervous system influenced late-phase renin release during hypotension, but not the early phase.
    • Intrarenal infusion of cAMP, DbcAMP, and CaCl2 significantly increased renin release.

    Conclusions:

    • Renin secretion is linked to the autoregulatory capacity of afferent arterioles, not solely to blood flow or pressure changes.
    • The beta-adrenergic receptor-adenyl cyclase-cAMP pathway is integral to renin secretion control.
    • Intracellular calcium distribution, influenced by cAMP, plays a role in augmenting renin release.