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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview

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Related Experiment Video

Updated: Jun 24, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Vanishing bone disease: review and case reports.

Stamatios A Papadakis1, Lubna Khaldi, Eleni C Babourda

  • 1Department of Orthopedics, General Hospital of Didimoticho, Athens, Greece.

Orthopedics
|March 19, 2009
PubMed
Summary

Vanishing bone disease causes extensive bone loss due to vascular and fibrous tissue proliferation. This rare condition

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Area of Science:

  • Orthopedics
  • Pathology
  • Radiology

Background:

  • Vanishing bone disease (Gorham-Stout disease) is a rare idiopathic condition characterized by progressive loss of bone.
  • Etiology is speculative, prognosis unpredictable, and effective therapy remains elusive.
  • Over 191 cases have been reported, with monostotic or polyostotic involvement.

Observation:

  • This report details two histologically confirmed cases of vanishing bone disease.
  • Case 1: Destructive lesion of the left humerus.
  • Case 2: Complete disappearance of the femoral head.

Findings:

  • Radiographic studies revealed significant bone destruction.
  • Laboratory and hormonal tests excluded metabolic, immunologic, neoplastic, or infectious causes.
  • Histopathology showed thickened lamellar bone adjacent to fibrous tissue with vascular proliferation.

Implications:

  • The disease's unpredictable prognosis ranges from mild disability to fatal outcomes.
  • Treatment remains controversial, with surgical intervention often considered.
  • Further research is needed to understand the etiology and develop effective therapies.