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Compact Bone

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...

Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Fractures: Bone Repair

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

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The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

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Published on: August 4, 2022

Coralline hydroxyapatite in complex acetabular reconstruction.

Ray C Wasielewski¹, Kate C Sheridan, Melissa A Lubbers

¹Minimally Invasive Orthopedics Inc., 500 E Main St, Ste 240, Columbus, OH 43215, USA.

|March 19, 2009

Summary

This summary is machine-generated.

Coralline hydroxyapatite bone grafts effectively repaired acetabular defects in complex reconstructions. Bone incorporation was observed, with no graft resorption, indicating a viable bone graft substitute for acetabular revision surgery.

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Area of Science:

Orthopedic surgery
Biomaterials science
Regenerative medicine

Background:

Complex acetabular reconstructions present challenges in achieving adequate bone defect repair.
Bone graft substitutes are crucial for successful acetabular revision surgery.
Coralline hydroxyapatite has shown potential as a bone graft material.

Purpose of the Study:

To evaluate the efficacy of coralline hydroxyapatite bone graft substitute (Pro Osteon 500) in complex acetabular reconstructions.
To assess bone incorporation and resorption of the graft material over time.
To determine the re-revision rates for acetabular cups following reconstruction with this graft substitute.

Main Methods:

Retrospective study of 17 patients undergoing acetabular revision.
Assessment of radiographic evidence for bone incorporation into the graft.
Evaluation of graft resorption.
Monitoring of acetabular cup re-revision rates.

Main Results:

No acetabular cups required re-revision due to graft failure, though one cup failed for other reasons.
Radiographic evidence confirmed bone incorporation into all coralline hydroxyapatite grafts.
No significant resorption of the coralline hydroxyapatite grafts was observed.

Conclusions:

Coralline hydroxyapatite bone graft substitute (Pro Osteon 500) demonstrates adequate repair of bone defects in complex acetabular reconstructions.
The material facilitates bone incorporation and does not exhibit significant resorption, supporting its use in acetabular revision.
This bone graft substitute shows promise for improving outcomes in challenging acetabular reconstruction cases.