Consistent new bone formation in 95 revisions: average 9-year follow-up
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Updated: Jun 24, 2026

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
Published on: February 7, 2025
George Mantelos1, Panagiotis Koulouvaris, Hlias Kotsovolos
1Department of Orthopedics, University Hospital of Ioannina, Department of Orthopedics, Greece.
Abstract:
This study evaluates the use of Wagner cementless stem for femurs with marked loss of proximal bone stock. Ninety-five hips in 89 patients were revised with a Wagner stem and prospectively studied. The indications were as follows: aseptic loosening for 84 hips, periprosthetic fracture for 5, Girdlestone for 3, mechanical loosening for 2 and recurrent dislocation for 1. The mean follow-up was 108 months (range, 84-180 months; SD, 13.5). There was only 1 re-revision, 2 months after surgery, and the survival rate at 9 years was 98.5%. The mean Merle d'Aubigné score improved from 8.8 to 16.1 (P<0.001). There were 15 (15.8%) intraoperative fractures, 5 (5.3%) dislocations, 2 (2.1%) thrombosis, and 2 (2.1%) sciatic neuropraxia. Significant bone formation occurred around the Wagner stem in 97% of the hips in these cases. No radiolucency or loosening had been diagnosed at the last follow-up.
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