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Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
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Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface

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In vitro models of inhalation toxicity and disease. The report of a FRAME workshop

Kelly BéruBé1, Michaela Aufderheide, Damien Breheny

  • 1Lung and Particle Research Group, School of Biosciences, Cardiff University, Cardiff, Wales. berube@cf.ac.uk

Alternatives to Laboratory Animals : ATLA
|March 19, 2009
PubMed
Abstract

No abstract available in PubMed .

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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