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Oxidative stress in children on peritoneal dialysis

Danuta Zwolinska1, Wladyslaw Grzeszczak, Maria Szczepanska

  • 1Department of Paediatric Nephrology, Wroclaw Medical University, Wroclaw, Poland. nefped@nefped.am.wroc.pl

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|March 19, 2009
PubMed

Insights

Children with chronic kidney disease (CKD) on peritoneal dialysis (PD) show lower antioxidant levels, including glutathione (GSH) and vitamins A, E, and C. This may contribute to increased oxidative stress in pediatric PD patients.

Area of Science:

  • Pediatric Nephrology
  • Oxidative Stress Research
  • Nutritional Biochemistry

Background:

  • Adults with chronic kidney disease (CKD) exhibit elevated oxidative stress, linked to higher mortality.
  • Nonenzymatic antioxidant defenses in pediatric CKD patients on peritoneal dialysis (PD) are understudied.

Purpose of the Study:

  • To quantify plasma, erythrocyte, and dialysate concentrations of glutathione (GSSG and GSH) and vitamins A, E, and C.
  • To investigate antioxidant status in children with CKD undergoing PD.

Main Methods:

  • Study included 10 children on PD and 27 age-matched healthy controls.
  • Measured concentrations of GSSG, GSH, and vitamins A, E, and C in plasma, erythrocytes, and dialysate.

Main Results:

  • PD patients had lower erythrocyte and plasma GSH.
  • Plasma GSSG was significantly higher in PD patients.
  • Children on PD showed decreased plasma concentrations of vitamins A, E, and C, with documented loss into ultrafiltrate.

Conclusions:

  • Reduced erythrocyte GSH activity and low plasma levels of vitamins A, E, and C may drive heightened oxidative stress in pediatric PD patients.
  • Findings highlight potential nutritional deficiencies and antioxidant imbalances in children with CKD on PD.
Abstract

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