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Related Experiment Video

Updated: Jun 24, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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Electrophysiological correlates of default-mode processing in macaque posterior cingulate cortex.

Benjamin Y Hayden1, David V Smith, Michael L Platt

  • 1Department of Neurobiology, Center for Neuroeconomic Studies, Center for Cognitive Neuroscience, Duke University School of Medicine, Durham, NC 27710, USA. hayden@neuro.duke.edu

Proceedings of the National Academy of Sciences of the United States of America
|March 19, 2009
PubMed
Summary

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The posterior cingulate cortex (CGp) regulates task engagement and vigilance. Higher CGp neural activity predicts errors and inattention, suggesting its role in the brain's default network.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • Moment-to-moment variations in vigilance significantly impact cognitive processes and behavior.
  • The neural mechanisms underlying dynamic changes in task engagement remain largely unknown.
  • The posterior cingulate cortex (CGp) is implicated in default-mode processing, but its role in vigilance control is unclear.

Purpose of the Study:

  • To investigate the hypothesis that the posterior cingulate cortex (CGp) controls dynamic variations in task engagement and vigilance.
  • To identify the neuronal substrates governing fluctuations in attention during daily activities.

Main Methods:

  • Single-neuron recordings were conducted in the CGp of two macaque monkeys.
  • Monkeys performed tasks requiring varying levels of vigilance, from attentive to inattentive states.

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Last Updated: Jun 24, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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  • Neural activity patterns were analyzed in relation to behavioral performance and task conditions.

    • Main Results:

    • CGp neuronal firing rates were suppressed during active task performance and elevated during rest periods between trials.
    • Higher CGp firing rates were correlated with increased errors and slower behavioral responses.
    • These activity patterns were distinct from those observed in the lateral intraparietal area, a region associated with the frontoparietal attention network.

    Conclusions:

    • The findings provide physiological evidence that the CGp mediates exteroceptive vigilance.
    • The results support the role of the CGp as part of the default network involved in regulating task engagement.