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Updated: Jun 24, 2026
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
Effect of Fas -670 A/G gene polymorphism on corneal allograft endothelial rejection
Hamid Reza Jahadi Hosseini1, Eskandar Kamali Sarvestani, Mitra Akbari
1Department of Ophthalmology, Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. jahadih@sums.ac.ir
Background:
Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene.
Objective:
The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation.
Methods:
In 276 graft recipients who mainly underwent penetrating keratoplasty because of keratoconus, bullous keratopathy and corneal opacity, Fas -670 A/G polymorphism was determined by allele specific oligonucleotide polymerase chain reaction (ASO-PCR) techniques.
Results:
There was no statistically significant relationship between Fas -670 A/G polymorphism and rejection episode (p=0.35). Moreover, the relationship between this polymorphism and rejection episode outcome (transplant recovery vs failure) was not statistically significant (p=0.13).
Conclusion:
The results of the present study show no significant correlation between corneal graft rejection, rejection recovery and Fas -670A/G gene polymorphism.
