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Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
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Published on: February 14, 2011

Two unusual cases of histoplasmosis in human immunodeficiency virus-infected individuals

P V Bhagwat1, K Hanumanthayya, R S Tophakhane

  • 1Department of Skin and STD, Karnataka Institute of Medical Sciences, Hubli-580 022, Karnataka, India. sharadapbhagwat@yahoo.com

Indian Journal of Dermatology, Venereology and Leprology
|March 19, 2009
PubMed

Insights

Histoplasmosis, a fungal infection caused by Histoplasma capsulatum, can present with oral lesions, especially in individuals with human immunodeficiency virus (HIV). Early diagnosis and consideration of this infection are crucial for effective management.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Histoplasmosis, caused by Histoplasma capsulatum, is endemic in certain regions.
  • Disseminated histoplasmosis frequently occurs in immunocompromised individuals, particularly those with HIV.
  • Oral manifestations are common in histoplasmosis patients, affecting 30-50%.

Observation:

  • Two cases of histoplasmosis in India are presented.
  • Case 1: Disseminated histoplasmosis with extensive skin and oral lesions in an HIV-positive patient.
  • Case 2: Tongue ulcer in an HIV-positive patient, diagnosed as histoplasmosis.

Findings:

  • Histoplasmosis diagnosis can be challenging, with limited culture confirmations in India.
  • Oral lesions are significant indicators of histoplasmosis, especially in HIV-infected individuals.
  • The study highlights the importance of considering histoplasmosis in the differential diagnosis of oral lesions in HIV patients.

Implications:

  • Increased awareness of histoplasmosis as a cause of oral lesions in HIV patients is necessary.
  • Prompt diagnosis and treatment of histoplasmosis can improve outcomes in immunocompromised individuals.
  • Further research on histoplasmosis epidemiology and diagnostics in India is warranted.

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