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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

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Updated: Jun 24, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

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Published on: June 28, 2021

Hypertriglyceridemic pancreatitis: presentation and management.

Wayne Tsuang1, Udayakumar Navaneethan, Luis Ruiz

  • 1Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.

The American Journal of Gastroenterology
|March 19, 2009
PubMed
Summary
This summary is machine-generated.

Severe hypertriglyceridemia (serum triglyceride levels >1,000 mg/dl) can cause acute pancreatitis. Management strategies like insulin and apheresis are explored, but large studies are needed for optimal guidelines.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolic Disorders

Background:

  • Hypertriglyceridemia (HTG) is a known cause of acute pancreatitis (AP), accounting for 1-4% of cases.
  • HTG is also implicated in over half of gestational pancreatitis cases.
  • Causes of HTG include primary genetic disorders and secondary factors like diabetes, hypothyroidism, and obesity.

Purpose of the Study:

  • To review the current understanding of hypertriglyceridemic pancreatitis (HTGP).
  • To discuss the postulated mechanisms and management strategies for HTGP.
  • To highlight the need for further research in HTGP management.

Main Methods:

  • Review of existing literature on HTG and AP.
  • Analysis of small studies evaluating management options for HTGP.
  • Discussion of anecdotal evidence from case series on HTGP prevention.

Main Results:

  • Serum triglyceride levels exceeding 1,000 mg/dl are typically required to establish HTGP causation.
  • Proposed mechanism involves pancreatic lipase hydrolysis of triglycerides, releasing free fatty acids and causing oxidative damage.
  • Evaluated management options include insulin, heparin, and apheresis, with anecdotal success in preventing recurrent AP through HTG control.

Conclusions:

  • HTGP is a significant complication of severe hypertriglyceridemia.
  • Current management involves controlling HTG through various therapeutic interventions.
  • Large-scale, multicenter studies are essential to develop evidence-based guidelines for HTGP management.