Related Experiment Video

Updated: Jun 24, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Uncontrolled airway inflammation in lung disease represents a defect in counter-regulatory signaling

Anna Planaguma1, Bruce D Levy

  • 1Pulmonary & Critical Care Medicine, Brigham & Women's Hospital & Harvard Medical School, 75 Francis St, Boston, MA 02115, USA Tel.: +1 617 525 8362 anna_planaguma@yahoo.es.

Future Lipidology
|September 28, 2011
PubMed

Insights

Defects in producing lipid mediators like lipoxins, resolvins, and protectins impair airway inflammation resolution. Understanding these mediators offers new insights into chronic airway diseases such as asthma.

Area of Science:

  • Immunology
  • Biochemistry
  • Pulmonary Medicine

Background:

  • Airway inflammation involves counter-regulatory lipid mediators crucial for resolution.
  • Defects in these mediators are linked to persistent airway inflammatory diseases.
  • Lipoxins, resolvins, and protectins are key anti-inflammatory and proresolving lipid mediators.

Purpose of the Study:

  • To review the role of lipoxins, resolvins, and protectins in airway inflammation.
  • To explore how these mediators impact the pathophysiology of chronic airway diseases.
  • To highlight the connection between diminished mediator formation and interrupted inflammation resolution.

Main Methods:

  • Literature review of emerging information on lipid mediators.
  • Analysis of the role of lipoxins, resolvins, and protectins in inflammation.
  • Examination of their involvement in chronic airway diseases, including asthma.

Main Results:

  • Lipoxins, resolvins, and protectins are critical for resolving airway inflammation.
  • Reduced production of these mediators disrupts the natural resolution process.
  • Emerging data links these mediators to the pathophysiology of chronic airway inflammation.

Conclusions:

  • Lipoxins, resolvins, and protectins are essential endogenous signals for inflammation resolution.
  • Dysfunction in these lipid mediator pathways contributes to chronic airway inflammation.
  • Further research into these mediators may reveal new therapeutic strategies for asthma and related conditions.

More Related Videos

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses08:16

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

Published on: July 7, 2017

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...