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Updated: Jun 24, 2026
Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
Interleukin-1 gene cluster polymorphisms and gingival recessions after orthodontic treatment
Loredana Bergandi1, Rachele Rubiano, Matteo Brunazzo
1Department of Genetics, Biology and Biochemistry, University of Torino, Italy.
Introduction:
Genetic polymorphisms in the interleukin-1 gene cluster have been associated with the severity of periodontal diseases featured by a variable degree of destruction of connective tissue and bone, such as periodontitis and periimplantitis. This study was aimed to investigate if a link exists between such interleukin-1 gene polymorphisms and the development of gingival recessions during orthodontic treatment in Italian children.
Methods:
We evaluated, in 74 young Italian patients of both sexes, the -889 C/T polymorphism of the interleukin-1alpha gene and the -511 C/T and +3954 C/T polymorphisms of interleukin-1alpha gene by polymerase chain reactions-restriction fragment length polymorphism method using NcoI, AvaI and TaqI as restriction enzymes.
Results:
No association of interleukin-1 genotypes investigated and gingival recession occurring during orthodontic treatment were identified.
Conclusion:
In the population studied specific interleukin-1 genotypes (linked to a higher susceptibility to bone resorption in periodontal disease) there does not appear to be any association with the development of gingival recessions during orthodontic treatment.
