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Related Experiment Video

Updated: Jun 24, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Triple therapy in refractory detrusor overactivity: a preliminary study.

Ricardo Natalin¹, Leonardo Oliveira Reis, Cristiano Alpendre

¹Division of Urology, University of Campinas, UNICAMP, Campinas, SP, 13073-090, Brazil.

World Journal of Urology

|March 19, 2009

Summary

Triple therapy, combining antimuscarinic, alpha-blocker, and tricyclic antidepressants, effectively treats refractory detrusor overactivity (DO). This approach improves bladder capacity and reduces symptoms, with manageable side effects.

Related Experiment Videos

Last Updated: Jun 24, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Area of Science:

Urology
Pharmacology

Background:

Refractory detrusor overactivity (DO) presents significant challenges in treatment.
Current therapeutic options for DO may be limited or associated with side effects.

Purpose of the Study:

To prospectively evaluate the efficacy and tolerability of a three-drug therapy for refractory DO.
The regimen includes an antimuscarinic, an alpha-blocker, and tricyclic antidepressants.

Main Methods:

A prospective study involving 27 patients with refractory DO.
Patients completed daily urinary charts and underwent urodynamic evaluation (UD) pre- and post-treatment.
Treatment response was defined as one or fewer involuntary detrusor contractions (IDC) on post-treatment UD.

Main Results:

Significant improvements were observed in bladder capacity, urgency, urge-incontinence, and frequency.
Urodynamic evaluation showed a significant increase in mean maximum bladder capacity (MBC) from 200 to 300 mL (P < 0.001).
The Overactive Bladder Questionnaire (OAB-v8) scores significantly improved (P < 0.01); common side effects included dry mouth and constipation.

Conclusions:

Three-drug therapy is a potentially effective, accessible, and well-tolerated treatment for refractory DO.
Further research is warranted to confirm these findings and establish consistent data.