Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[French national standard for the treatment of squamous cell carcinoma of upper aero-digestive tract - General principles of treatment].

Bulletin du cancer·2024
Same author

[National standard for the treatment of squamous cell carcinoma of upper aerodigestive tract].

Bulletin du cancer·2024
Same author

Functional or radical surgical treatment of laryngeal chondrosarcoma, analysis of survival and prognostic factors: A REFCOR and NetSarc-ResOs multicenter study of 74 cases.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2024
Same author

Minimally invasive fully ROBOT-assisted cochlear implantation in humans: Preliminary results in five consecutive patients.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2021
Same author

Resensitization to Nivolumab after Intratumoral Chemotherapy in Recurrent Head and Neck Squamous Cell Cancer: A Report of 2 Cases.

Case reports in oncology·2020
Same author

Effect of nasal airway nonlinearities on oscillometric resistance measurements in infants.

Journal of applied physiology (Bethesda, Md. : 1985)·2020
Same journal

Comment on "Experts V/S AI´s 2.0: comparative evaluation of ai models and expert consensus in obstructive sleep apnea assessment".

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same journal

Adenoid-Nasopharyngeal Ratio and craniofacial growth in Children: A two-center longitudinal study with threshold and causal analyses.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same journal

Association of multidisciplinary team management with survival in sinonasal malignancies: a real-world IPTW cohort study.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same journal

Epidemiology of obstructive sleep apnea in a Danish rural population - cross-sectional data from the Lolland-Falster Health Study.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same journal

Pharyngocutaneous fistula following total laryngectomy: a systematic review of risk factors and management strategies (2010-2024).

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same journal

"MELMA" in otolaryngology: Medical evaluation of large language model answers. Clinician-rated scoring (MELMA-Q) and web-based auditing (MELMA-W) novel tools for AI assessment.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

'Aggressive papillary' thyroid microcarcinoma.

Cyril Page1, Aurélie Biet, Pierrick Boute

  • 1Department of Anatomy, University Medical School of Amiens, University of Picardie Jules Verne, Amiens, France. cyril.page@caramail.com

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|March 19, 2009
PubMed
Summary
This summary is machine-generated.

Papillary thyroid microcarcinoma can exhibit aggressive behavior. Aggressive cases, identified by specific risk factors, necessitate treatment comparable to larger differentiated thyroid cancers.

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Related Experiment Videos

Last Updated: Jun 24, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Head and Neck Surgery

Background:

  • Papillary thyroid microcarcinoma (PTMC) management remains debated.
  • Aggressive features in PTMC can mimic larger differentiated thyroid cancers.

Purpose of the Study:

  • To underscore the aggressive potential of PTMC.
  • To advocate for therapeutic strategies for aggressive PTMC based on risk factors.

Main Methods:

  • Retrospective analysis of 187 thyroid cancer patients over 8 years.
  • Identification of 65 PTMC cases, with 41 classified as aggressive based on defined criteria (size >5mm, multifocality, capsular invasion, vascular/lymphatic spread).
  • Treatment protocols included total thyroidectomy, radioactive iodine ((131)I) therapy, and varying degrees of neck dissection.

Main Results:

  • No recurrence or metastasis observed in aggressive PTMC patients post-treatment (follow-up 6 months to 8 years).
  • Aggressive PTMC, defined by prognostic factors, was identified in a significant subset of patients.
  • Surgical interventions were tailored based on individual risk profiles.

Conclusions:

  • Aggressive PTMC is not uncommon and warrants assertive therapeutic approaches.
  • Treatment decisions for PTMC should be guided by the presence or absence of specific prognostic risk factors.
  • Aggressive PTMC management may involve total thyroidectomy, (131)I, and lymph node dissection, similar to differentiated thyroid cancers.