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Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...
Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Traumatic Memory01:20

Traumatic Memory

Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual remembers mundane...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

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Related Experiment Video

Updated: Jun 24, 2026

System for Focal, Closed-System Central Nervous System Injury
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System for Focal, Closed-System Central Nervous System Injury

Published on: November 29, 2024

Post-traumatic headache: facts and doubts.

Rita Formisano1, Umberto Bivona, Sheila Catani

  • 1Post-Coma Unit and Headache Center, IRCCS Fondazione Santa Lucia, Rome, Italy. r.formisano@hsantalucia.it

The Journal of Headache and Pain
|March 19, 2009
PubMed
Summary
This summary is machine-generated.

Post-traumatic headache (PTH) diagnosis in traumatic brain injury (TBI) patients needs better criteria than the current 3-month window. Severe TBI cases show fewer PTH cases but may have organic lesions, unlike mild TBI with psychological issues.

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Area of Science:

  • Neurology
  • Neuroscience
  • Pain Medicine

Background:

  • Current classifications inadequately address headache severity in traumatic brain injury (TBI).
  • Glasgow Coma Scale (GCS) < 13 defines moderate to severe TBI, lacking nuance for headache assessment.
  • The 3-month parameter for post-traumatic headache (PTH) occurrence/resolution may be insufficient due to variable coma and amnesia durations.

Purpose of the Study:

  • To evaluate the characteristics and diagnostic challenges of post-traumatic headache (PTH) in severe traumatic brain injury (TBI).
  • To explore the relationship between TBI severity, coma duration, and the development of PTH.
  • To investigate the correlation between PTH, cognitive function, and psychopathological changes post-TBI.

Main Methods:

  • Analysis of TBI patients with a focus on headache presentation and severity.
  • Assessment of coma duration, post-traumatic amnesia, and Glasgow Coma Scale (GCS) scores.
  • Evaluation of cognitive functioning, psychopathological status (anxiety, depression), and organic findings (skull fractures, EEG abnormalities) at 1-year follow-up.

Main Results:

  • Fewer TBI patients with longer coma duration and more severe TBI presented with PTH at 1-year follow-up.
  • Severe TBI patients with PTH often exhibited skull fractures, dural lacerations, and EEG abnormalities.
  • Psychopathological changes like anxiety and depression were noted, particularly in severe TBI patients with good cognitive recovery.

Conclusions:

  • The 3-month timeframe for PTH assessment is likely inadequate for severe TBI.
  • PTH in severe TBI is associated with organic lesions, contrasting with psychological disturbances in mild TBI.
  • Affective pain perception in TBI patients may depend on cognitive function integrity.