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10:33
Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
Infectious uveitis in Thailand: serologic analyses and clinical features
Wasna Sirirungsi1, Kessara Pathanapitoon, Natedao Kongyai
1Division of Clinical Microbiology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. asmbi001@chiangmai.ac.th
Ocular Immunology and Inflammation
|March 19, 2009
Summary
Toxoplasma gondii antibodies were more common in Thai patients with non-HIV posterior uveitis. This finding was significant compared to controls and HIV patients with retinitis, indicating a higher seroprevalence in this specific group.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Immunology
Background:
- Uveitis is a significant cause of vision loss.
- Identifying infectious agents is crucial for managing uveitis.
- Seroprevalence studies help understand disease epidemiology.
Purpose of the Study:
- To determine the seroprevalence of infectious agents in Thai patients with uveitis.
- To compare seroprevalence between non-HIV uveitis patients, HIV-infected retinitis patients, and controls.
- To investigate the association of specific infections with uveitis subtypes.
Main Methods:
- Prospective study involving 101 consecutive patients with uveitis.
- Included 100 HIV-infected retinitis patients and 100 nonuveitis controls for comparison.
- Serological testing for various infectious agents was performed.
Main Results:
- Antibodies against Toxoplasma gondii (T. gondii) were detected in 31/101 non-HIV patients with uveitis.
- T. gondii seroprevalence was significantly higher in non-HIV posterior uveitis patients compared to controls and HIV patients.
- Antibodies for Treponema pallidum and Leptospira were more frequent in HIV-infected retinitis patients.
Conclusions:
- Toxoplasma gondii is a significant infectious agent associated with non-HIV posterior uveitis in Thailand.
- The seroprevalence of T. gondii antibodies is notably higher in this patient group.
- Further research may elucidate the role of T. gondii in the pathogenesis of posterior uveitis.
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