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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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A supramolecular polymer as a self-assembling polyvalent scaffold.

Marion K Müller1, Luc Brunsveld

  • 1Department of Chemical Biology, Max Planck Institute for Molecular Physiology and Chemical Genomics Centre, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.

Angewandte Chemie (International Ed. in English)
|March 19, 2009
PubMed
Summary

Discotic molecules form supramolecular polymers that bind strongly to bacteria using mannose ligands. This reversible self-assembly allows for optimized bacterial aggregation through simple monomer mixing.

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Area of Science:

  • Supramolecular chemistry
  • Materials science
  • Microbiology

Background:

  • Bacteria pose significant health challenges.
  • Targeted bacterial binding is crucial for diagnostics and therapeutics.
  • Supramolecular polymers offer novel platforms for molecular recognition.

Purpose of the Study:

  • To develop discotic molecules that self-assemble into supramolecular polymers for bacterial binding.
  • To investigate the role of mannose ligands in polyvalent binding to bacteria.
  • To explore the potential of reversible self-assembly for optimizing bacterial aggregation.

Main Methods:

  • Synthesis of discotic molecules with peripheral mannose ligands.
  • Characterization of self-assembly into columnar supramolecular polymers.
  • Evaluation of bacterial binding affinity and specificity.
  • Assessment of monomer mixing for tuning aggregation properties.

Main Results:

  • Discotic molecules successfully self-assembled into columnar supramolecular polymers.
  • The supramolecular polymers exhibited strong polyvalent binding to bacteria.
  • Mannose ligands on the polymer periphery were essential for bacterial recognition.
  • Reversible polymer formation enabled simple optimization of bacterial aggregation.

Conclusions:

  • Discotic supramolecular polymers with mannose ligands provide an effective strategy for bacterial binding.
  • The reversible nature of self-assembly allows for tunable control over bacterial aggregation.
  • This approach holds promise for applications in bacterial detection and removal.