Related Experiment Video
Updated: Jun 24, 2026

Exploring Protein-Glycan Interactions: Advances in Nuclear Magnetic Resonance
Published on: August 26, 2025
Evidence for C-Cl/C-Br...pi interactions as an important contribution to protein-ligand binding affinity
Hans Matter1, Marc Nazaré, Stefan Güssregen
1Sanofi-Aventis Deutschland GmbH, Discovery Research, Industriepark Höchst, Building G878, 65926 Frankfurt am Main, Germany. hans.matter@sanofi-aventis.com
Abstract:
Attractive chlorine: Noncovalent interactions between chlorine or bromine atoms and aromatic rings in proteins open up a new method for the manipulation of molecular recognition. Substitution at distinct positions of two factor Xa inhibitors improves the free energy of binding by interaction with a tyrosine unit. The generality of this motif was underscored by multiple crystal structures as well as high-level quantum chemical calculations (see picture).
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