Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
Quantitative Aspects of Drug-Receptor Interaction01:30

Quantitative Aspects of Drug-Receptor Interaction

The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower Kd...
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Modeling with Differential Equations01:25

Modeling with Differential Equations

Population dynamics can be described mathematically by considering the population size P(t) as a function of time. The rate of change of the population is then represented by the derivative of P(t). A simple assumption is that the rate of growth is proportional to the size of the population itself. This leads to an exponential growth model, where the population increases rapidly without bound. While this is a useful first approximation, it does not reflect realistic long-term...
Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conflicts and Collisions With an Endangered Carnivore: Landscape Drivers and Spatial Risk Pattern.

Ecology and evolution·2026
Same author

Impact of Wearing a Face Mask on the Reliability of Standard Automated Perimetry in Glaucoma Patients and Suspects: a Retrospective Longitudinal Study.

Klinische Monatsblatter fur Augenheilkunde·2026
Same author

Fragmentation as a population rate-changer: A field experiment.

Ecology·2026
Same author

Changes in phenology mediate vertebrate population responses to temperature globally.

Nature communications·2026
Same author

The functional effects of African lions on co-occurring carnivores differ across species pairs and with changes in resource availability and lion abundance.

Oecologia·2026
Same author

Using Deep Learning to Automate Orangutan Nest Detections on Aerial Images Collected With Drones.

American journal of primatology·2025

Related Experiment Video

Updated: Jun 24, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Perturbation analysis for patch occupancy dynamics.

Julien Martin1, James D Nichols, Carol L McIntyre

  • 1Florida Cooperative Fish and Wildlife Research Unit, University of Florida, Gainesville, Florida 32611-0485, USA. julienm@ufl.edu

Ecology
|March 20, 2009
PubMed
Summary
This summary is machine-generated.

This study introduces sensitivity metrics for patch occupancy dynamics, revealing how vital rates impact species equilibrium. These metrics help assess colonization and extinction effects on population ecology and management.

More Related Videos

A Computer-assisted Multi-electrode Patch-clamp System
11:01

A Computer-assisted Multi-electrode Patch-clamp System

Published on: October 18, 2013

Related Experiment Videos

Last Updated: Jun 24, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

A Computer-assisted Multi-electrode Patch-clamp System
11:01

A Computer-assisted Multi-electrode Patch-clamp System

Published on: October 18, 2013

Area of Science:

  • Ecology
  • Population Dynamics
  • Mathematical Biology

Background:

  • Perturbation analysis is crucial for understanding population and community dynamics.
  • Patch occupancy models are widely used to study species distribution and abundance.
  • Vital rates (colonization and extinction) are key drivers of population dynamics.

Purpose of the Study:

  • To develop and present expressions for sensitivity metrics in patch occupancy dynamics.
  • To assess the impact of changes in vital rates on equilibrium occupancy.
  • To apply these metrics to Golden Eagle (Aquila chrysaetos) population ecology and management.

Main Methods:

  • Derivation of sensitivity metric expressions for patch occupancy dynamics.
  • Application of patch occupancy models to estimate vital rates and equilibrium occupancy.
  • Case study using Golden Eagle nesting territory data.

Main Results:

  • The study system satisfies equilibrium conditions.
  • Sensitivity metrics were computed, demonstrating their utility in ecological analysis.
  • Predictions were made regarding the relative importance of colonization vs. extinction probabilities for species occupancy.

Conclusions:

  • Sensitivity metrics provide valuable insights into factors influencing population equilibrium.
  • The approach is applicable to both rare and common species.
  • Perturbation analysis enhances ecological understanding and aids in conservation and management strategies.